Cholinergic dysfunction after traumatic brain injury

• DOI: 10.1212/wnl.0b013e318211c1c4
• Publication Date: 2011-03-21T20:53:28Z
• Authors: A. Östberg; J. Virta; J.O. Rinne; V. Oikonen; P. Luoto; K. Någren; E. Arponen; O. Tenovuo
• Keywords: Adult; Male; Brain Mapping; Brain; Acetates; Middle Aged; Radioligand Assay; 03 medical and health sciences; 0302 clinical medicine; Piperidines; Brain Injuries; Positron-Emission Tomography; Acetylcholinesterase; ta319; Humans; Female; Carbon Radioisotopes; Cognition Disorders; ta999

There is evidence that the cholinergic system frequently involved in cognitive consequences of traumatic brain injury (TBI). We studied whether function altered after TBI vivo using PET.Cholinergic was assessed with [methyl-(11)C]N-methylpiperidyl-4-acetate, which reflects acetylcholinesterase (AChE) activity, 17 subjects more than 1 year a and 12 healthy controls. All had been without any centrally acting drugs for at least 4 weeks.The AChE activity significantly lower compared to controls several areas neocortex (-5.9% -10.8%, p=0.053 0.004).Patients chronic symptoms show widely lowered across neocortex.