Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment

• DOI: 10.1212/wnl.0b013e31826c1a8d
• Publication Date: 2012-08-23T06:19:53Z
• Authors: Lukas Scheef; Annika Spottke; Moritz Daerr; Alexius Joe; Nadine Striepens; Heike Kölsch; Julius Popp; Marcel Daamen; Dominik Gorris; Michael T. Heneka; Henning Boecker; Hans J. Biersack; Wolfgang Maier; Hans H. Schild; Michael Wagner; Frank Jessen
• Keywords: Gray (unit); Memory Impairment; Carbohydrate Metabolism

To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance to investigate the longitudinal course these subjects.[¹⁸F]fluoro-2-deoxyglucose PET (FDG-PET) structural MRI were acquired 31 subjects SMI 56 controls. Cognitive follow-up testing was performed (average time: 35 months). Differences baseline brain imaging data decline assessed between both groups. Associations of tested.The group showed hypometabolism right precuneus hypermetabolism medial temporal lobe. Gray matter volume reduced hippocampus group. At follow-up, a poorer than controls on measures episodic memory. Longitudinal associated glucose metabolism at baseline.The cross-sectional difference 2 independent neuroimaging modalities indicates early AD pathology SMI. The association support concept as earliest manifestation AD.