α-[ 11 C]-Methyl- l -tryptophan–PET in 191 patients with tuberous sclerosis complex

• DOI: 10.1212/wnl.0b013e3182a08f3f
• Publication Date: 2013-07-13T03:33:23Z
• Authors: Harry T. Chugani; Aimee F. Luat; Ajay Kumar; Rajkumar Govindan; Kathy Pawlik; Eishi Asano
• Keywords: Adult; Male; Adolescent; Tryptophan; Brain; Infant; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Tuberous Sclerosis; Child, Preschool; Positron-Emission Tomography; Humans; Female; Carbon Radioisotopes; Radiopharmaceuticals; Child

This was an observational study done on a large cohort of patients with tuberous sclerosis complex (TSC) to determine whether i) the presence α-[(11)C]-methyl-l-tryptophan (AMT) hotspots is related duration seizure intractability, ii) AMT specific TSC gene mutations, and iii) there concordance between areas hotspot lateralization/localization scalp EEG.One hundred ninety-one (mean age: 6.7 years; median: 5 range: 3 months 37 years) intractable epilepsy were included. All underwent AMT-PET scan. uptake in each tuber normal-appearing cortex measured correlated clinical, EEG, and, if available, electrocorticographic data.The longer greater number (r = 0.2; p 0.03). seen both TSC1 TSC2. There excellent agreement focus lateralization ictal EEG (Cohen κ 0.94) 68 95 whom video-EEG showed lateralizing findings; 28 (41%), more localizing. Furthermore, localizing 10 17 (58%) nonlateralized EEG.AMT-PET, when used together video-EEG, provides additional data, regardless mutation. The intractability may predict multiplicity hotspots.