Alzheimer's disease

• DOI: 10.1212/wnl.33.8.961
• Publication Date: 2012-05-13T12:29:22Z
• Authors: Norman L. Foster; Thomas N. Chase; Paul Fedio; Nicholas J. Patronas; Rodney A. Brooks; Giovanni Di Chiro
• Keywords: Parietal lobe; Language function; Frontal lobe; Temporal cortex

Local rates of cortical glucose metabolism were estimated by positron emission tomography in 13 right-handed patients with Alzheimer's disease. Individuals disproportionate failure language function had markedly diminished the left frontal, temporal, and parietal regions. Patients predominant visuo-constructive dysfunction evidenced a hypometabolic focus right cortex. memory as most apparent feature no significant metabolic asymmetry In all subjects, verbal competency generally correlated activity frontal temporal areas, while test performance was linked to utilization lobe.