Pseudo-Continuous Arterial Spin Labeling is Sensitive to Changes in Cerebral Blood Flow in Semantic Variant Primary Progressive Aphasia and Non-fluent/Agrammatic Primary Progressive Aphasia (P5.004)

• DOI: 10.1212/wnl.84.14_supplement.p5.004
• Publication Date: 2023-12-06T23:42:28Z
• Authors: Christopher Olm; Benjamin Kandel; Brian Avants; John Detre; James Gee; Corey McMillan; Murray Grossman
• Keywords: Primary progressive aphasia; Aphasiology; Arterial spin labeling; Primary (astronomy)

OBJECTIVE: To assess the regions of hypoperfusion in patients with semantic variant primary progressive aphasia (svPPA) and non-fluent/agrammatic (naPPA) using pseudo-continuous arterial spin labeling (PCASL) MRI. BACKGROUND: Frontotemporal degeneration (FTD) is a neurodegenerative condition characterized by focal atrophy frontal temporal cortex. Functional imaging has been proposed as method for measuring changes cerebral blood flow (CBF) that precede structural disease. PCASL MRI non-invasive relatively inexpensive measure CBF. METHODS: We acquired T1 data same session on FTD two distinct clinical presentations: naPPA (N=17) svPPA (N=17). used ANTs software to generate gray matter (GM) probability mean CBF images from data, respectively. performed whole-brain voxel-wise two-sample t-tests compare GM partial volume effects-corrected controls controls, between patient groups. RESULTS: Relative showed left dorsolateral inferior cortex other regions, well posterior regions. Patients displayed relative anterior lobe had bilateral regions. CONCLUSIONS: Both groups overlapping atrophied cortical Hypoperfusion was also seen some not corresponding atrophy. Furthermore, we found differences direct comparison groups. Together, these findings suggest ASL provides converging evidence disease can be imaging, may sensitive functional apparent MRI. Study Support: NIH Grants AG017586, AG-015116, NS044266, AG032953, Wyncote Foundation. Disclosure: Dr. Olm nothing disclose. Kandel Avants Detre received personal compensation activities Methodist Hospital Stanford University lecturer. Gee McMillan Grossman