Is Intrathecal Magnesium Sulfate Safe and Protective Against Ischemic Spinal Cord Injury in Rabbits?

• DOI: 10.1213/01.ane.0000138039.04548.3d
• Publication Date: 2004-11-17T09:04:03Z
• Authors: Hiroshi Saeki; Mishiya Matsumoto; Shuichi Kaneko; Shunsuke Tsuruta; Ying Jun Cui; Kazunobu Ohtake; Kazuyoshi Ishida; Takefumi Sakabe
• Keywords: Neurotoxicity; Histopathology

We performed three sets of experiments to investigate the safety intrathecal magnesium and determine its optimal dose for protection, if any, against ischemic spinal cord injury in rabbits. First, we examined neurotoxicity 0.3, 1, 2, or 3 mg/kg sulfate (n = 6 each). Significant sensory dysfunction was observed 3-mg/kg group 7 days after administration. Motor found two rabbits both 2- groups. The area destruction laminae V-VII one, two, one rabbit 1-, 2-, groups, respectively. Second, investigated temporal profile (6 h, 48 96 h [n each]) histopathologic changes confirmed similar with motor at h. Third, evaluated effects 0.3 1 saline each) administered before ischemia on hindlimb function histopathology (15 min). Magnesium did not improve neurologic outcome reperfusion. results indicate that has a risk shows no evidence protective injury.