Continuous Low-Dose Ketamine Improves the Analgesic Effects of Fentanyl Patient-Controlled Analgesia After Cervical Spine Surgery

• DOI: 10.1213/ane.0b013e31817f1e4a
• Publication Date: 2008-08-13T07:15:44Z
• Authors: Masanori Yamauchi; Makoto Asano; Masanori Watanabe; Soushi Iwasaki; Shingo Furuse; Akiyoshi Namiki
• Keywords: Male; Analgesics; Pain, Postoperative; Analgesia, Patient-Controlled; Middle Aged; Spine; 3. Good health; Analgesics, Opioid; Fentanyl; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; General Surgery; Humans; Female; Ketamine; Aged

In Brief BACKGROUND: The effects of fentanyl with ketamine for postoperative pain are unknown. We investigated the adjuvant patient-controlled analgesia. METHODS: Cervical and lumbar spine surgery patients were divided into three groups: 1 mg/kg followed by 42 83 μg · kg−1 h−1 in ketamine-1 ketamine-2 group, respectively, a control group. Postoperative analgesia was administered background infusion. RESULTS: Pain scores requirement group significantly lower than those after cervical surgery. Ketamine partially improved analgesic CONCLUSION: Small-dose IMPLICATIONS: (2 mg 24 h−1) but not