The Postoperative Analgesic Efficacy of Preperitoneal Continuous Wound Infusion Compared to Epidural Continuous Infusion with Local Anesthetics After Colorectal Cancer Surgery

• DOI: 10.1213/ane.0b013e31826b4694
• Publication Date: 2012-11-13T13:11:38Z
• Authors: Sergio Bertoglio; Fabio Fabiani; Pasquale De Negri; Antonio Corcione; Domenico Franco M...; Ferdinando Cafiero; Clelia Esposito; Claudio Belluco; Davide Pertile; Riccardo Amodio; Matilde Mannucci; Valeria Fontana; Marcello De Cicco; Lucia Zappi
• Keywords: Ropivacaine

Open colorectal cancer (CRC) surgery induces severe and prolonged postoperative pain. The optimal method of analgesia in CRC has not been established. We evaluated the efficacy preperitoneal continuous wound infusion (CWI) ropivacaine for after open a multicenter randomized controlled trial.Candidates randomly received CWI or epidural (CEI) with 0.2% 10 mL/h 48 hours surgery. Fifty-three patients were allocated to each group. All patient-controlled IV morphine analgesia.Over 72-hour period end surgery, was inferior CEI analgesia. difference mean visual analog scale score between 1.89 (97.5% confidence interval = -0.42, 4.19) at rest 2.76 -2.28, 7.80) coughing. Secondary points, consumption rescue analgesia, did differ groups. Time first flatus 3.06 ± 0.77 days group 3.61 1.41 (P 0.002). stool shorter than (4.49 0.99 vs 5.29 1.62 days; P 0.001). Mean time hospital discharge (7.4 0.41 8.0 0.38 days, respectively). More reported excellent quality pain control (45.3% 7.6%). Quality night sleep better particularly evaluation 0.009). Postoperative nausea vomiting significantly less frequent 24 0.02), 0.01), 72 0.007) evaluations.Preperitoneal during provided effective relief