[Homozygous Variant of

• DOI: 10.12182/20240560207
• Publication Date: 2024-05-20
• Authors: Xingxing Wen; Menghan Chai; Qiannan Zhang; Huijuan Zou; Zhiguo Zhang; Yunxia Cao; Beili Chen

Infertility affects approximately one-sixth of the people childbearing age worldwide, causing not only economic burdens treatment for families with fertility problems but also psychological stress patients and presenting challenges to societal development. Premature ovarian insufficiency (POI) refers loss function in women before 40 due depletion follicles or decreased quality remaining follicles, constituting a significant cause female infertility. In recent years, help rapid development genetic sequencing technology, it has been demonstrated that factors play crucial role onset POI. Among population suffering from POI, studies have revealed genes involved processes such as meiosis, DNA damage repair, mitosis account 37.4% all pathogenic potentially identified. FA complementation group M (