The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2

• DOI: 10.1242/bio.20134382
• Publication Date: 2013-04-19T03:20:05Z
• Authors: Jos Van Rijssel; Ilse Timmerman; Floris P. J. Van ...; Mark Hoogenboezem; Olexandr Korchynskyi; Dirk Geerts; Judy Geissler; Kris A. Reedquist; Hans W. M. Niessen; Jaap D. Van Buul
• Keywords: Leukocyte extravasation

Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger leukocyte extravasation. Central this event increased gene transcription. Small Rho-GTPases not only control the actin cytoskeleton, but are also implicated in regulation. However, inflammation, it clear how regulated. Here, we show guanine-nucleotide exchange factor Trio expression upon inflammatory stimuli endothelium. Additionally, was found vessel wall of rheumatoid arthritis patients. silencing impaired VCAM-1 expression. Finally, excluded Trio-controlled used classical NFκB or MAP-kinase pathways, rather acts on transcriptional level increasing phosphorylation and nuclear translocalization Ets2. These data implicate regulating inflammation provide novel targets for therapeutic purposes treat diseases such as arthritis.