Neural crest cell lineage segregation in the mouse neural tube

• DOI: 10.1242/dev.01533
• Publication Date: 2004-11-18T01:14:23Z
• Authors: Yvette M. Wilson; Kay L. Richards; Miriam L. Ford-Pe...; Jean-Jacques Pant...; Mark Murphy
• Keywords: Hindbrain; Neural fold; Lineage (genetic); Proto-Oncogene Proteins c-kit; Neuroepithelial cell; Cell type; Precursor cell

Neural crest (NC) cells arise in the dorsal neural tube (NT) and migrate into embryo to develop many different cell types. A major unresolved question is when how fate of NC decided. There widespread evidence for multipotential cells, whose fates are decided during or after migration. also some that already divided subpopulations discrete precursors within NT. We have investigated this mouse embryo. find a subpopulation on most dorsomedial aspect NT express receptor tyrosine kinase Kit (previously known as c-kit), emigrate exclusively developing dermis, then definitive markers melanocyte lineage. These thus progenitor cells. They generated predominantly at midbrain-hindbrain junction cervical trunk, with significant numbers lower trunk. Other Kit-, ventrally, and, from embryonic day 9.5, neurotrophin p75. likely only give rise ventral derivatives such neurons glia. The p75+ located ventrolateral Kit+ areas where these two types found. data provide direct vivo lineage segregation tube.