Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement duringDrosophilametamorphosis

• DOI: 10.1242/dev.02728
• Publication Date: 2006-12-14T02:53:36Z
• Authors: Nikolay Ninov; Dominic A. Chiarelli; Enrique Martín-B...
• Keywords: Epidermis (zoology); Tadpole (physics)

The fusion of epithelial sheets is an essential morphogenetic event. Here, we study the development abdomen Drosophila as a model bounded epithelia expansion and uncover complex multistep process for generation adult epidermis from histoblasts, founder cells that replace larval during metamorphosis. We find histoblasts experience biphasic cell cycle emit apical projections direct their invasive planar intercalation in between cells. Coordinately, extrude by constriction actomyosin ring consequence die apoptosis are removed circulating haemocytes. demonstrate proliferation death triggered two independent extrinsic Ecdysone hormonal pulses. Finally, show histoblast spreading depend on mutual exchange signals non-autonomous processes.