DPP-mediated TGFβ signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase

• DOI: 10.1242/dev.057687
• Publication Date: 2011-05-10T13:23:54Z
• Authors: Jianhua Huang; Ling Tian; Cheng Peng; Mohamed Abdou; Di Wen; Ying Wang; Sheng Li; Jian Wang
• Keywords: Corpus allatum

Juvenile hormone (JH) biosynthesis in the corpus allatum (CA) is regulated by neuropeptides and neurotransmitters produced brain. However, little known about how these neural signals induce changes JH biosynthesis. Here, we report a novel function of TGFβ signaling transferring brain into transcriptional acid methyltransferase (jhamt), key regulatory enzyme A Drosophila genetic screen identified that Tkv Mad are required for JH-mediated suppression broad (br) expression young larvae. Further investigation demonstrated stimulates upregulating jhamt expression. Moreover, dpp hypomorphic mutants also induced precocious br The pupal lethality was partially rescued an exogenous agonist. Finally, specifically expressed CA cells ring glands, its profile correlated with matched levels hemolymph. Reduced detected larvae mutant Nmdar1, CA-expressed glutamate receptor. Taken together, conclude neurotransmitter promotes CA, which through transcription at early larval stages to prevent premature metamorphosis.