Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons

• DOI: 10.1242/dev.099531
• Publication Date: 2013-08-15T13:10:41Z
• Authors: Chie Satou; Yukiko Kimura; Hiromi Hirata; Maximiliano L. Su...; Koichi Kawakami; Shin-ichi Higashi...
• Keywords: Progenitor

The developing nervous system consists of a variety cell types. Transgenic animals expressing reporter genes in specific classes neuronal cells are powerful tools for the study network formation. We generated wide transgenic zebrafish that expressed neurons or progenitors. These include lines which neurotransmitter phenotypes fluorescent proteins Gal4, and subsets dorsal progenitor domain spinal cord proteins. Using these, we examined organization cord, found there six domains zebrafish, is similar to mice. also systematically characterized properties produced from each domain. Given gene expressions occurs area generated, these fish should serve as investigation not only but structures functions many other regions system.