The Drosophila retinoid X receptor homolog ultraspiracle functions in both female reproduction and eye morphogenesis

• DOI: 10.1242/dev.115.2.449
• Publication Date: 2021-04-26T01:03:01Z
• Authors: Anthony E. Oro; Michael Mckeown; Ronald M. Evans
• Keywords: Retinoid X receptor; Cell fate determination

Abstract ultraspiracle (usp) encodes the Drosophila cognate of RXR, human retinoid X receptor. To examine how RXR subfamily members function in development, we have undertaken a phenotypic analysis usp mutants. is required at multiple stages development for functions that occur wide variety tissues, eye-antennal imaginal disc normal eye morphogenesis and somatic germline tissues adult females fertilization, eggshell embryonic development. An unusual sunken phenotype with marked ventral-dorsal polarity appears to be caused by lack cells reside between antennal anlage. The include cell autonomous non-cell components, suggesting controls production factors important both cell-cell communication cellular differentiation. These signalling pathways mechanistic parallels steroid action developing vertebrate tissues.