Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila

• DOI: 10.1242/dev.125.4.667
• Publication Date: 2021-04-23T19:24:34Z
• Authors: Lisa A. Moore; Heather Tarczy Br...; Mark Van Doren; Lynn B. Lunsford; Ruth Lehmann
• Keywords: Germ layer; Germ line development

ABSTRACT Gonadogenesis in the Drosophila embryo is a complex process involving numerous cellular migratory steps and cell-cell interactions. The mechanisms guiding germ cells to move through, recognize adhere specific cell types are poorly understood. In order identify genes that required for these processes, we have conducted an extensive mutagenesis of third chromosome screened mutations disrupting migration at any point embryonic development. Phenotypic analysis mutants demonstrates can be broken down into discrete developmental steps, with each step requiring set genes. Many involved development gonadal mesoderm, tissue associates form gonad. Moreover, isolated affecting patterning as well suggest origin mesoderm lies within eve domain developing mesoderm.