Slow as Molasses is required for polarized membrane growth and germ cell migration inDrosophila

• DOI: 10.1242/dev.129.16.3925
• Publication Date: 2021-04-26T05:02:27Z
• Authors: Jennifer A. Stein; Heather Tarczy Br...; Lisa A. Moore; Ruth Lehmann
• Keywords: Blastoderm; Germ plasm

Drosophila germ cell migration is directed by attractive and repulsive guidance cues. We have identified a novel gene, slow as molasses (slam), which required for migration. In slam zygotic mutants, cells fail to transit off the midgut into mesoderm. show that at this stage in parallel HMG Coenzyme A reductase, previously gene. Removal of both maternal results an earlier defect: failure form cellular blastoderm. Consistent with phenotype, we found one earliest genes be transcribed embryo, Slam protein localizes growing basal-lateral membrane during blastoderm formation, but not detected later stages embryogenesis. Because RNA are expressed than time when observe defects migration, propose localization signal basal side needed posterior guide cells.