Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae

• DOI: 10.1242/jcs.161463
• Publication Date: 2015-01-15T05:51:59Z
• Authors: Jagan Mohan; Björn Morén; Elin Larsson; Mikkel Holst; Richard Lundmark
• Keywords: Caveolin 1; Caveolin

Caveolae are invaginations of the cell surface thought to regulate membrane tension, signalling, adhesion and lipid homeostasis due their dynamic behaviour ranging from stable association rounds fission fusion with plasma membrane. The caveolae coat is generated by oligomerisation protein caveolin family cavin proteins. Here, we show that cavin3 targeted cavin1 where it interacts scaffolding domain caveolin1 promote dynamics. We found N-terminal region binds a trimer N-terminus in competition homologous cavin2 region, showing cavins form distinct subcomplexes via regions. Our data shows enriched at deeply invaginated loss cells results an increase decrease short duration time propose recruited interact