Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration

• DOI: 10.1242/jcs.231993
• Publication Date: 2019-10-21T13:55:19Z
• Authors: Ana S. Brandão; Anabela Bensimon-...; Raquel Lourenço; Jorge Borbinha; Ana Rosa Soares; Rita Mateus; António Jacinto
• Keywords: Hippo signaling pathway

Osteoblast differentiation is a key process for bone homeostasis and repair. Multiple signalling pathways have been associated with osteoblast differentiation, yet much remains unknown on how this regulated in vivo Previous studies proposed that the Hippo pathway transcriptional co-activators YAP TAZ (also known as YAP1 WWTR1, respectively) maintain progenitor stemness inhibit terminal of osteoblasts, whereas others suggest they potentiate formation. Here, we use zebrafish caudal fin regeneration model to clarify regulates de novo formation differentiation. We demonstrate Yap inhibition leads accumulation osteoprogenitors prevents cell non-autonomous manner. This effect correlates severe impairment Bmp likely by suppressing expression ligand bmp2a surrounding mesenchymal cells. Overall, our findings provide new mechanism through Hippo-Yap pathway, integrating cascade governs osteoprogenitor maintenance subsequent during regeneration.