Serotonin, but not dopamine, controls stress response and anxiety-like behavior in crayfish, Procambarus clarkii.

• DOI: 10.1242/jeb.120550
• Publication Date: 2015-07-03T14:52:20Z
• Authors: Pascal Fossat; Julien Bacqué-Caz...; Philippe De Deurw...; Daniel Cattaert; Jean-Paul Delbecque
• Keywords: Procambarus clarkii

In the animal kingdom, biogenic amines are widespread modulators of nervous system that frequently interact in control mood. Our previous investigations crayfish (Procambarus clarkii) have established stress induces changes brain serotonin (5-HT) concentrations responsible for appearance anxiety-like behavior (ALB). The following study further analyzes roles 5-HT and another amine, dopamine (DA), on response to stress. Results showed intensity ALB depended stressful stimulation was associated with increased brain. These levels were significantly correlated, before, as well after stress, those DA, which approximately 3-5 times less abundant. However, whereas clearly correlated concentrations, it not DA. Moreover, contrary 5-HT, DA injections able elicit ALB. Incidentally, modified by treatment anxiolytic chlordiazepoxide, confirming suppression this ligand GABA-A receptors acted downstream independently from bioamine levels. also provided evidence anxiogenic effect can be prevented a preliminary injection antagonists. Altogether, our results emphasize rises but play role controlling induction