Thyroglobulin Measurement Through Fine-Needle Aspiration for Optimizing Neck Node Dissection in Papillary Thyroid Cancer

• DOI: 10.1245/s10434-021-10549-2
• Publication Date: 2021-08-12T19:02:22Z
• Authors: Xi Jia; Yuanbo Wang; Yan Liu; Xiang Wang; Xiaobao Yao; Runyi Tao; Hui Liu; Aimin Yang; Rui Gao
• Keywords: Neck dissection; Thyroglobulin; Surgical oncology

Thyroglobulin measurement in fine-needle aspiration (FNA-Tg) is an additional diagnostic tool of lymph node metastasis (LNM) papillary thyroid carcinoma (PTC). However, its performance as a preoperative indicator lateral neck LNM PTC unclear. We evaluated the use FNA cytology and FNA-Tg to detect presurgery using simple methodology, established cut-off value for diagnosing PTC.We performed retrospective cohort study based on hospital records, including 299 measurements from 228 patients with PTC. The was obtained through receiver operating characteristic (ROC) curve analysis. relationships between various parameters were analyzed Spearman's correlation.Of nodes (LNs) following surgery, 151 malignant 148 benign. median levels 414.40 ng/mL 6.36 metastatic benign LNs, respectively. An 28.3 had best (93.38% sensitivity, 70.27% specificity, area under ROC [AUC] 0.868) whole cohort. better group (level II-V, n = 163) than central VI, 136); group, sensitivity specificity (16.8 ng/mL) 96.25% 96.36%, respectively.FNA-Tg useful technique diagnosis before especially dissection.ChiCTR1900028547.