The Asymmetric Hydrocyanation of Aldehydes with Cyanotrimethylsilane Promoted by a Chiral Titanium Reagent

• DOI: 10.1246/cl.1987.2073
• Publication Date: 2006-07-25T03:01:36Z
• Authors: Koichi Narasaka; Tohru Yamada; Hiroyuki Minamikawa
• Keywords: Hydrocyanation; Cyanohydrin

The asymmetric hydrocyanation of aldehydes with cyanotrimethylsilane proceeds by the use a chiral alkoxy titanium(IV) to give corresponding cyanohydrins good enantioselectivity.