Bromine K-Edge X-Ray Absorption Near-Edge Structure Analysis on Hydrobromide-Salt Crystals and the Solid Dispersion of Active Pharmaceutical Ingredients

• DOI: 10.1248/cpb.c21-00912
• Publication Date: 2022-01-31T22:09:24Z
• Authors: Hironori Suzuki; Asumi Tomita; Masataka Ito; Shuji Noguchi
• Keywords: X-Ray Absorption Spectroscopy; 0404 agricultural biotechnology; Molecular Structure; Pharmaceutical Preparations; Salts; 04 agricultural and veterinary sciences; Bromine; Catalysis; Hydrocarbons, Brominated

Bromine K-edge X-ray absorption near-edge structure (XANES) spectroscopy analyses were used to evaluate the crystals of the active pharmaceutical ingredients, eletriptan hydrobromide, dextromethorphan hydrobromide and scopolamine hydrobromide salts and the solid dispersion of eletriptan hydrobromide. The crystals and the solid dispersion of the active pharmaceutical ingredient (API) salts could be discriminated based on the shape of the XANES spectra. The differences in the shape of XANES spectra was ascribable to the differences in the interatomic interactions of the bromine ions based on the crystal structures. Ratio of the eletriptan hydrobromide α-form crystal in mixed powders of α-form and monohydrate crystals could be quantified by the linear-combination fitting using their XANES spectra. These results indicated that the XANES spectroscopy are a potent method for evaluating the APIs of pharmaceutical formulations even at the higher energy region around the bromine K-edge of 13470 eV.