Influence of Dynamic Training on Hemodynamic, Neurohormonal Responses to Static Exercise and on Inflammatory Markers in Patients After Coronary Artery Bypass Grafting

• DOI: 10.1253/circj.cj-10-0104
• Publication Date: 2010-10-11T05:20:18Z
• Authors: Maria Bilinska; Magdalena Kosydar...; Anna Gasiorowska; Tomasz Mikulski; Walerian Piotrowski; Krystyna Nazar; Ryszard Piotrowicz
• Keywords: Male; Neurotransmitter Agents; Hemodynamics; Stroke Volume; Middle Aged; Nitric Oxide; Exercise Therapy; 3. Good health; 03 medical and health sciences; Catecholamines; 0302 clinical medicine; Humans; Coronary Artery Bypass; Inflammation Mediators; Exercise; Biomarkers; Retrospective Studies

Background: Little is known about the influence of dynamic training on hemodynamic and neurohormonal responses to static exercise inflammatory markers in optimally treated post-coronary artery bypass grafting (CABG) patients. Methods Results: One hundred twenty male patients, aged 55±6 years, 3 months after receiving CABG, were randomized either 6 weeks aerobic a cycloergometer, times week, at 70-80% maximum tolerated heart rate (HR) (training group, n=60) or control group (n=60). At baseline end study, all patients underwent: (1) cardiopulmonary test; (2) handgrip 30% maximal voluntary contraction for 3min sitting position during which HR, blood pressure (BP), stroke volume (SV, by impedance cardiography), cardiac output (CO) total peripheral resistance (TPR) monitored; (3) plasma level assessment catecholamines, nitric oxide markers. During final tests, handgrip-induced increases BP, TPR (14% vs 27%, P<0.01) lower, whereas SV CO higher (by 13% 15%, respectively, P<0.05) trained compared with controls. Moreover, increase (46% 14%, lower noradrenaline (11% 20%, observed Accordingly, caused significant improvement peak oxygen uptake per kilogram body weight (peak VO2) Conclusions: Short-term handgrip, cardiovascular fitness state. (Circ J 2010; 74: 2598-2604)