Prognostic Impact of Acute Kidney Injury in Patients With Acute Decompensated Heart Failure

• DOI: 10.1253/circj.cj-12-0994
• Publication Date: 2012-11-30T22:56:44Z
• Authors: Akihiro Shirakabe; Noritake Hata; Nobuaki Kobayashi; Takuro Shinada; Kazunori Tomita; Masafumi Tsurumi; Masato Matsushita; Hirokake Okazaki; Yoshiya Yamamoto; Shinya Yokoyama; Kuniya Asai; Kyoichi Mizuno
• Keywords: Acute kidney failure

Background: The relationship between acute kidney injury (AKI) in the phase of decompensated heart failure (ADHF) and patient outcome has not yet been reported. Methods Results: Data for 625 patients with ADHF admitted to intensive care unit were analyzed. No AKI occurred 281 (no AKI) during first 5 days. assigned 3 groups based on timing: present admission stable risk, injury, failure, loss, endstage (RIFLE) class (stable early AKI; n=125), stepped-up RIFLE (worsening n=49), or that after (late n=170). grouped into another severity: R (risk; n=214), I (injury; n=73), F (failure; n=57). A multivariate logistic regression model found I, F, late worsening be independently associated in-hospital mortality. Kaplan-Meier survival curves showed rate any-cause death 2 years was significantly lower early-AKI group, there more HF events group. There Conclusions: presence admission, AKI, severe (class F) are a poorer prognosis patients. (Circ J 2013; 77: 687–696)