Impact of Age on the Functional Significance of Intermediate Epicardial Artery Disease

• DOI: 10.1253/circj.cj-15-1402
• Publication Date: 2016-05-18T22:06:21Z
• Authors: Xiongjie Jin; Hong-Seok Lim; Seung-Jea Tahk; Hyoung-Mo Yang; Myeong-Ho Yoon; So-Yeon Choi; Byoung-Joo Choi; Andy S. C. Yong; William F. Fearon; Seung Soo Sheen; Kyoung-Woo Seo; Joon-Han Shin
• Keywords: Fractional Flow Reserve; Intravascular Ultrasound; Lumen (anatomy)

Background:The functional significance of an intermediate coronary lesion is crucial for determining the treatment strategy, but age-related changes in cardiovascular function could affect epicardial stenosis. The aim this study was therefore to investigate impact age on fractional flow reserve (FFR) measurements patients with artery disease (CAD).Methods and Results:Intracoronary pressure intravascular ultrasound (IVUS) were performed 178 left anterior descending arteries morphological characteristics FFR 91 lesions <65 years old compared those 87 ≥65 old. There no difference location, diameter stenosis, minimum lumen area, plaque burden, or length between 2 groups. Elderly had higher (0.81±0.06 vs. 0.79±0.06, P=0.004) lower ∆FFR, defined as resting Pd/Pa (0.13±0.05 0.15±0.05, P=0.014). Age, along location degree independently associated ∆FFR (β=0.162, P=0.008; β=−0.131, P=0.043, respectively).Conclusions:Elderly CAD are more likely have despite a similar younger patients. (Circ J 2016; 80: 1583–1589)