Peroxisomal fitness plays a crucial role forpreventing adipocyte dysfunction and obesity

• DOI: 10.1254/jpssuppl.92.0_jkp-07
• Publication Date: 2020-03-19T22:21:44Z
• Authors: Jiang S; Piao L Ha H.
• Keywords: Lipotoxicity

Peroxisome is a critical organelle for fatty acid oxidation (FAO) and metabolismof reactive oxygen species (ROS). Increased oxidative stress in white adiposetissue (WAT) crucial the development of insulin resistance metabolicsyndrome obesity. The present study aimed to investigate role ofperoxisomal fitness maintaining adipocyte function. Reduced adiposeperoxisomal genes obesity suggested close correlation between peroxisomesand Pex5 siRNA increased cellular ROS inflammatory mediators in3T3-L1 adipocytes. On other hands, H2O2 or TNFα treatment decreasedperoxisomal genes. Therefore, vicious cycle ROS/inflammation andperoxisomal dysfunction may apparently exacerbate adipose dysfunction.Correspondingly, catalase (a major peroxisomal antioxidant) deficiency mice withhigh-fat diet exhibited severe stress, suppressed genes,and accelerated Fenofibrate, proliferator, increasedperoxisomal biogenesis wild-type, but not PPAR-α null obese mice. Restorationof was parallel with attenuated metabolic phenotypes andimproved FAO Adipose homeostasis plays animportant modulating phenotype which can be apotential therapeutic target