The cognitive function of the mice with an exonic deletion of RELN is impaired in touchscreen-based visual discrimination task

• DOI: 10.1254/jpssuppl.93.0_1-ss-33
• Publication Date: 2020-03-17T22:05:35Z
• Authors: Geyao Dong; Taku Nagai; Jingzhu Liao; Daisuke Mori; Bolati Wulaer; Toshitaka Nabeshima; Norio Ozaki; Kiyofumi Yamada
• Keywords: Touchscreen

Touchscreen-based cognitive tasks have been developed for rodents to provide a better translational approach across species further understanding of the impairment observed in various neuropsychiatric disorders. Reelin protein (RELN), an extracellular matrix protein, plays important role embryonic neuronal migration and development laminar structure cerebral cortex. In present study, we aimed explore performance RELN-deletion (include exons 52 58) mice, using touchscreen-based visual discrimination (VD) task. Mice were initially trained discriminate between pair stimuli simultaneously displayed on screen received liquid reward. The function was impaired RELN deletion mice as demonstrated by increased total, total errors, correction trials sessions complex VD task reversal learning. We that is mice.