Comparison of two radiation techniques for the breast boost in patients undergoing neoadjuvant treatment for breast cancer

• DOI: 10.1259/bjr.20160264
• Publication Date: 2016-07-25T11:04:29Z
• Authors: Maria C De Santis; Luigia Nardone; Barbara Diletto; Roberta Canna; Michela Dispinzieri; Lorenza Marino; Laura Lozza; Vincenzo Valentini
• Keywords: Adult; Radiology, Nuclear Medicine and Imaging; Radiotherapy Planning, Computer-Assisted; Breast Neoplasms; Heart; Radiotherapy Dosage; Middle Aged; Mastectomy, Segmental; Neoadjuvant Therapy; 3. Good health; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Antineoplastic Combined Chemotherapy Protocols; Humans; Female; Dose Fractionation, Radiation; Neoplasm Grading; Radiometry; Tomography, X-Ray Computed; Aged; Neoplasm Staging; Retrospective Studies

After breast conservative surgery (BCS) and whole-breast radiotherapy (WBRT), the use of boost irradiation is recommended especially in patients at high risk. However, standard technique definition volume have not been well defined.We retrospectively compared an anticipated pre-operative photon on tumour, administered with low-dose fractionated radiotherapy, neoadjuvant chemotherapy two different sequential techniques, after BCS adjuvant WBRT: (1) a beam (2) electron tumour bed same patients. The plans were analyzed for dosimetric coverage CT-delineated irradiated volume. minimal dose received by 95% target (D95), 90% (D90) geographic misses evaluated.15 evaluated. techniques resulted inferior technique, median D95 96.3% (range 94.7-99.6%) 0.8% 0-30%) D90 99.1% 90.2-100%) 54.7% 0-84.8%), respectively. We observed miss 26.6% plans. results better: 99.4% 96.5-100%) 97.1% 86.2-99%) D95, respectively, no was observed. reduction to heart, left-sided irradiation, using when all dose-volume parameters. When plans, showed higher ipsilateral lung Dmax.Our data show that better respect while also saving organs risk consequently fewer side effects.This first study evaluated association between treatment.