Resveratrol Improves Endothelial Progenitor Cell Function through miR-138 by Targeting Focal Adhesion Kinase (FAK) and Promotes Thrombus Resolution In Vivo

• DOI: 10.12659/msm.906116
• Publication Date: 2018-02-15T18:13:06Z
• Authors: Yeqing Zhang; Xiaolong Du; Wendong Li; Hongfei Sang; Aimin Qian; Lili Sun; Xiaoqiang Li; Chenglong Li
• Keywords: Ex vivo; Endothelial progenitor cell

BACKGROUND:Endothelial progenitor cells (EPCs) were found to be a potential therapeutic choice for low extremity deep vein thrombosis. The aim of our research was investigate the effect resveratrol (RSV) on EPCs that may promote thrombus resolution and its pathway. MATERIAL AND METHODS:EPCs pretreated with RSV migration; angiogenesis evaluated ex vivo. Expression miR-138 focal adhesion kinase (FAK) also tested. A murine model venous thrombosis developed as an in vivo model. effects treatment mice inferior evaluated. RESULTS:We increased migration tube formation significantly inhibited expression. Moreover, we demonstrated FAK target revealed knockdown downregulated RSV-treated EPCs. In addition, RSV-induced promoted CONCLUSIONS:We first evidence intravenous injection enhanced exerted role by reducing expression therefore upregulated FAK.