High infectious disease burden as a basis for the observed high frequency of asymptomatic SARS-CoV-2 infections in sub-Saharan Africa

• DOI: 10.12688/aasopenres.13196.2
• Publication Date: 2021-06-07T14:40:09Z
• Authors: Kwadwo Asamoah Kusi; Augustina Frimpong; Frederica Dedo Pa...; Helena Lamptey; Linda Eva Amoah; Michael Fokuo Ofori
• Keywords: Pandemic; Cytokine Storm; Coronavirus

<ns3:p>Following the coronavirus outbreaks described as severe acute respiratory syndrome (SARS) in 2003 and Middle East (MERS) 2012, world has again been challenged by yet another corona virus, named 2 (SARS-CoV-2). SARS-CoV-2 infections were first detected a Chinese Province December 2019 then declared pandemic World Health Organization March 2020. An infection caused may result asymptomatic, uncomplicated or fatal disease (COVID-19). Fatal linked with uncontrolled “cytokine storm” manifesting complications mostly people underlying cardiovascular pulmonary conditions. The severity of COVID-19 associated mortality disproportionately lower terms number cases deaths Africa also Asia comparison to Europe North America. Also, persons colour residing America have identified highly susceptible population due combination several socioeconomic factors poor access quality healthcare. Interestingly, this not case sub-Saharan where majority are even more deprived aforementioned factors. On contrary, recorded lowest levels morbidity disease, an overwhelming proportion asymptomatic. Whilst it can be argued that these challenges diagnosis such lack trained personnel infrastructure, who get infected develop symptoms is proportionally than those including asymptomatic never diagnosed. This review discusses most probable reasons for significantly fewer Africa.</ns3:p>