Assessing use of vancomycin powder in craniotomy: randomized controlled trial (AVIC)

• DOI: 10.12688/f1000research.133032.1
• Publication Date: 2023-06-30T11:00:09Z
• Authors: Sirajeddin Belkhair; Muhammad Mohsin khan; Younis Baregzai; Khalida Walizada; Ahmed Eid; Ahmed Taha; Saleh Safi; Amr Mohammad; Abdullah llleyyan; Tarek Ben Zabih; Ali Raza; Adnan khan; Firas Hammadi; Raed Jarir; Ali Ayyad; Talal Alrabayah
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

<ns4:p><ns4:bold>Background: </ns4:bold>Surgical-site infections (SSIs) can lead to greater postoperative morbidity, mortality, and health care costs. Despite current prophylactic measures, rates of SSIs have been reported in up 5% patients post craniotomy. Intrawound vancomycin powder has studied extensively spinal fusion surgeries found reduce surgical site significantly. its success surgeries, topical not with respect cranial neurosurgery.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>Our study is Prospective Randomized clinical trial. Patients will be divided this Trial into two groups, first group (intervention arm) they receive the drug (vancomycin) wound before closure skin at end procedure. The second (control drug, otherwise both groups identical measure decrease SSI. primary outcome variable SSI rate factored by cohort. Secondary monitor safety any complication related use . around 0.49% when was used, while standard 5%, get power 80% level significance 5%. Sample size 250 each using sample calculator.</ns4:p><ns4:p> <ns4:bold>Discussion: </ns4:bold>This designed evaluate efficacy compared method neuro-surgical cases undergoing craniotomy Additionally, assessed these patients.</ns4:p>