Defining “FGF21 Resistance” during obesity: Controversy, criteria and unresolved questions

• DOI: 10.12688/f1000research.14117.1
• Publication Date: 2018-03-07T10:20:31Z
• Authors: Kathleen R. Markan
• Keywords: Open peer review; FGF21

<ns4:p>The term “FGF21 resistance” was first used to describe increased circulating FGF21 levels concomitant decreased receptor complex expression in white adipose tissue of obese mice. Since this initial report, the has been associated with a wide range pathological states, including human obesity, which are elevated. However, notion controversial partly due difficulty delineating mechanisms underlying physiological versus pharmacological effects FGF21. Here, key aspects discussed including; origin and experimental context surrounding resistance”, new criteria for evaluating sensitivity <ns4:italic>in vivo</ns4:italic> finally, crucial unresolved questions regarding function during obesity.</ns4:p>