Association of LEP rs2167270 and LEPR rs1137100 genetic variants with obesity in the Jordanian population cohort

• DOI: 10.12688/f1000research.142344.1
• Publication Date: 2024-06-11T16:42:18Z
• Authors: Manal Jarrar; Maen Hasan; Moawiya Haddad; Maher Obeidat; Ahmad Al-Qerem; M. Dulce Estêvão; Maria Palma Mateus
• Keywords: Genome-wide Association Study; Genetic Association

<ns4:p>Background Previous Genome Wide Association Studies (GWAS) of obesity susceptibility genes in different populations have confirmed the association some variants with obesity, body mass index (BMI), and related metabolic traits. To our knowledge, current study is first to investigate genetic basis Jordanian population. The aim occurrence frequency obesity-related individuals any possible relationship between SNP markers phenotypic characteristics studied individuals. Methods A total 150 unrelated adults, including 83 obese, 26 overweight, 41 normal-weight subjects, were genotyped using high resolution melt analysis (HRMA) tested for single nucleotide polymorphisms (SNPs), rs2167270 <ns4:italic>LEP</ns4:italic> gene rs1137100 <ns4:italic>LEPR</ns4:italic> gene, risk, obesity/overweight BMI, weight, height, cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, blood level glucose. Results significant risk mutation was observed under a dominant model (odds ratio (OR) = 2.5147, 95% CI =1.0629 5.9494, p 0.0358). marginal (not significant) BMI (p 0.075), also detected. Moreover, an glucose 0.038). Total cholesterol LDL-cholesterol presented weak 0.071 0.078, respectively. Additionally, no 0.091). By contrast, there weight or height SNPs evaluated this &gt; 0.05). Conclusions These results suggest that may contribute its anthropometric traits confirm these results, further studies on larger cohort should be carried out.</ns4:p>