The impact of CDK4/6 inhibitors on the quality of life of working-age women with metastatic breast cancer: a population-based cohort study from Portugal

• DOI: 10.12688/f1000research.142460.1
• Publication Date: 2024-01-18T12:40:05Z
• Authors: Ana Caetano; Alda Tavares; Mariana Pires; Cláudia Costa; Joana Monteiro; Ricardo Roque; Rita Santos; Luís Santos; Inês Gomes; Teresa Fraga; Tatiana Pereira; Sara Póvoa; Rita Garcia; António Pêgo; Pedro Madeira; Isabel Pazos; Sofia Broco; Teresa Carvalho; Gabriela Sousa
• Keywords: 03 medical and health sciences; 0302 clinical medicine

<ns4:p>Background Breast cancer frequently leads to reduced work capacity and increased absenteeism among working-age women diagnosed with this condition. In study, we aimed assess the effect of CDK4/6i combined aromatase inhibitors (AIs) or fulvestrant on quality life (QoL) activity in a cohort Portuguese patients hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) metastatic breast who started treatment regimen. Methods This unicentric prospective observational study was conducted 35 stage IV HR+/HER2- receiving therapy. The objectives were evaluated using European Organization for Research Treatment Cancer (EORTC) Quality Life Questionnaire C30 version 3 (QLQ-C30) cancer-specific (EORTC QLQ-BR23), Work Productivity Activity Impairment questionnaire - General Health (WPAI:GH) questionnaires at four different time points throughout treatment. Results results obtained revealed significant improvement EORTC QLQ-C30 score from baseline emotional functioning, social pain, dyspnea, insomnia, financial difficulties, as well future perspective symptoms, assessed by QLQ-BR23 score. However, deterioration systemic therapy side effects also observed. Despite limitations regarding size, an increase observed, determined WPAI:GH scores. can possibly be attributed pain-related bone metastases observed those patients. Conclusions To best our knowledge, is first impact QoL cancer. Our indicate that although patients’ did not appear affected, there decrease activity, evidenced preliminary rate absenteeism.</ns4:p>