A computational analysis of the long-term regulation of arterial pressure

• DOI: 10.12688/f1000research.2-208.v1
• Publication Date: 2013-10-08T10:26:55Z
• Authors: Daniel A. Beard; Klas H. Pettersen; Brian E. Carlson; Stig W. Omholt; Scott M. Bugenhagen
• Keywords: Mean arterial pressure

<ns4:p>The asserted dominant role of the kidneys in chronic regulation blood pressure and etiology hypertension has been debated since 1970s. At center theory is observation that acute relationships between arterial urine production—the pressure-diuresis pressure-natriuresis curves—physiologically adapt to perturbations and/or changes rate salt volume intake. These adaptations, modulated by various interacting neurohumoral mechanisms, result water excretion are much steeper than relationships. While view renal function controller supported computer models cardiovascular system known as “Guyton-Coleman model”, no unambiguous description a model capturing adaptation control presented. Here, such developed with goals of: 1. relevant mechanisms an identifiable mathematical model; 2. identifying parameters using appropriate data; 3. validating predictions comparison 4. probing hypotheses regarding long-term primary hypertension. The reveals: primarily through baroreflex arc renin-angiotensin system; stiffening provides sufficient explanation for associated ageing. Furthermore, first consistent physiological response stimulation baroreflex.</ns4:p>