Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells

• DOI: 10.12688/f1000research.7010.1
• Publication Date: 2015-12-17T10:25:05Z
• Authors: Xiaojing Ma; Wenjun Yan; Hua Zheng; Qinglin Du; Lixing Zhang; Yi Ban; Na Li; Fang Wei
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Review; 3. Good health

Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12.