Limiting adverse birth outcomes in resource-limited settings (LABOR): protocol of a prospective intrapartum cohort study

• DOI: 10.12688/gatesopenres.13716.2
• Publication Date: 2022-12-19T10:30:07Z
• Authors: Amanda Adu-Amankwah; Mrutunjaya B. Bellad; Aimee M. Benson; Titus K. Beyuo; Manisha Bhandankar; Umesh Charanthimath; Maureen Chisembele; Stephen R. Cole; Sangappa M. Dhaded; Christabel Enwero...; Bethany L. Freeman; Nikki L. B. Freeman; Shivaprasad S. Go...; Xiaotong Jiang; Margaret P. Kasaro; Michael R. Kosorok; Daniel Luckett; Felistas M. Mbewe; Sujata Misra; Kunda Mutesu; Mercy A. Nuamah; Samuel A. Oppong; Jackie K. Patterson; Marc Peterson; Teeranan Pokaprakarn; Joan T. Price; Yeshita V. Pujar; Dwight J. Rouse; Yuri V. Sebastião; M. Bridget Spelke; John Sperger; Jeffrey S. A. Str...; Methodius G. Tuuli; Michael Valancius; Bellington Vwalika
• Keywords: Alternative medicine; Maternal and Neonatal Outcomes of Cesarean Section; Preterm labor; Limiting; Resource (disambiguation); Social Sciences; Health Professions; FOS: Mechanical engineering; Adverse effect; Pediatrics; Study Protocol; 03 medical and health sciences; Fetus; Engineering; 0302 clinical medicine; Pregnancy; Health Sciences; Genetics; Pathology; Internal medicine; Biology; Demography; Global Maternal and Child Health Outcomes; Computer network; Mortality Forecasting; Cohort; Obstetrics and Gynecology; Computer science; Mechanical engineering; Impact of Trauma Care Systems on Mortality; FOS: Sociology; Obstetrics; Impact of Food Insecurity on Health Outcomes; Prospective cohort study; Childbirth; FOS: Biological sciences; Pediatrics, Perinatology and Child Health; General Health Professions; Protocol (science); Emergency Medicine; Population Ageing Research; Medicine; Emergency medicine; Cohort study; Cohort Analysis; Labor Induction

<ns4:p><ns4:bold>Background:</ns4:bold> Each year, nearly 300,000 women and 5 million fetuses or neonates die during childbirth shortly thereafter, a burden concentrated disproportionately in low- middle-income countries. Identifying their at risk for intrapartum-related morbidity death could facilitate early intervention.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> The Limiting Adverse Birth Outcomes Resource-Limited Settings (LABOR) Study is multi-country, prospective, observational cohort designed to exhaustively document the course outcomes of labor, delivery, immediate postpartum period settings where adverse are frequent. study conducted four hospitals across three countries Ghana, India, Zambia. We will enroll approximately 12,000 presentation hospital delivery follow them fetuses/newborns throughout labor course, hospitalization, up 42 days thereafter. co-primary composites maternal (death, hemorrhage, hypertensive disorders, infection) fetal/neonatal events encephalopathy, sepsis) that may be attributed intrapartum period. collects extensive physiologic data through use sensors employs medical scribes examination findings, diagnoses, medications, other interventions real time.</ns4:p><ns4:p> <ns4:bold>Discussion:</ns4:bold> goal this research produce large, sharable dataset can used build statistical algorithms prospectively stratify parturients according outcomes. anticipate inform development new tools reduce peripartum mortality low-resource settings.</ns4:p>