Complexity of options related to restarting oral poliovirus vaccine (OPV) in national immunization programs after OPV cessation

• DOI: 10.12688/gatesopenres.14511.1
• Publication Date: 2023-04-17T09:26:52Z
• Authors: Dominika A Kalkowska; Steven GF Wassilak; Eric Wiesen; Concepcion F Esti...; Cara C Burns; Kamran Badizadegan; Kimberly M Thompson
• Keywords: Poliomyelitis eradication; Disease Eradication

The polio eradication endgame continues to increase in complexity. With cases caused by wild poliovirus type 1 and circulating vaccine-derived polioviruses of all three types (1, 2 3) reported 2022, the number, formulation, use vaccines poses challenges for national immunization programs vaccine suppliers. Prior transmission modeling globally-coordinated type-specific cessation oral (OPV) assumed creation Sabin monovalent OPV (mOPV) stockpiles emergencies explored potential need restart if world reached a specified cumulative threshold number after cessation.