Prediction of Local Failures with a Combination of Pretreatment Tumor Volume and Apparent Diffusion Coefficient in Patients Treated with Definitive Radiotherapy for Hypopharyngeal or Oropharyngeal Squamous Cell Carcinoma

• DOI: 10.1269/jrr.10178
• Publication Date: 2011-06-03T12:41:15Z
• Authors: Kayoko OHNISHI; Yoshiyuki SHIOYAMA; Masamitsu HATAKENAKA; Katsumasa NAKAMURA; Koichiro ABE; Takashi YOSHIURA; Saiji OHGA; Takeshi NONOSHITA; Tadamasa YOSHITAKE; Torahiko NAKASHIMA; Hiroshi HONDA
• Keywords: Univariate analysis

Purpose: The purpose of this study was to investigate the clinical factors for predicting local failure after definitive radiotherapy in oropharyngeal or hypopharyngeal squamous cell carcinoma. Materials and Methods: Between July 2006 December 2008, 64 consecutive patients with carcinoma hypopharynx oropharynx treated were included study. Clinical factors, such as pretreatment hemoglobin (Hb) level, T-stage, gross tumor volume primary tumors (pGTV), maximum standardized uptake value (SUVmax) on FDG-PET, evaluated correlation failure. A subset analysis 32 MR images including diffusion-weighted (DWI) a evaluation also performed. Kaplan-Meier curves, log-rank test, Cox proportional hazards model used evaluate these factors. Results: Eleven experienced recurrence, median follow-up time 15 months. In univariate analysis, Hb level (p = 0.0261), T-stage 0.012), pGTV 0.0025), SUVmax 0.024) significantly associated multivariate 0.0070) remained an adverse factor control. DWI, apparent diffusion coefficient (ADC) DWI 0.79 × 10–3 mm2/s (range, 0.40–1.60 mm2/s). Patients high ADC (> mm2/s) had lower control rate than low (100% vs. 44%, p 0.0019). among large 55% (6/11), whereas no failures occurred (0%, 0/21) small ADC. Conclusions: These results suggest that combination could be predictive recurrence