Antihypertensive Effects and Endothelial Progenitor Cell Activation by Intake of Chicken Collagen Hydrolysate in Pre- and Mild-Hypertension

• DOI: 10.1271/bbb.80189
• Publication Date: 2009-02-24T05:57:58Z
• Authors: Ai SAIGA-EGUSA; Koji IWAI; Toru HAYAKAWA; Yoshihisa TAKAHATA; Fumiki MORIMATSU
• Keywords: Male; 0303 health sciences; Protein Hydrolysates; Stem Cells; Blood Pressure; Middle Aged; 03 medical and health sciences; Hypertension; Animals; Humans; Female; Collagen; Endothelium; Chickens; Antihypertensive Agents

Chicken collagen hydrolysate was given to 15 mildly hypertensive subjects for 4 weeks. Blood pressure was significantly decreased by 11.8 mmHg (P<0.01). A reduction in plasma renin activity was observed in blood test after intake. A colony assay of endothelial progenitor cells in blood samples from non-smokers revealed an approximately 30% increase in the number of colonies.