Variation in Gene Expression of Inflammatory Cytokines in Leukocyte-Derived Cells of High-Fat-Diet-Induced Insulin-Resistant Rats

• DOI: 10.1271/bbb.80259
• Publication Date: 2008-10-23T05:54:56Z
• Authors: Saki FUJIMOTO; Kazuki MOCHIZUKI; Masaya SHIMADA; Yuki MURAYAMA; Toshinao GODA
• Keywords: Proinflammatory cytokine

A high-fat diet is thought to enhance inflammation in various tissues by increasing insulin resistance. In this study, we determined the mRNA levels of inflammatory cytokines leukocyte-derived cells blood rats with high-fat-diet-induced Feeding a for 77 d induced moderate resistance, which was increased plasma glucose and concentrations, following an oral tolerance test. The interleukin (IL)-1β level higher insulin-resistant than control at fasting stage, whereas tumor necrosis factor (TNF)-α greatly elevated 180 min after administration rats. results suggest that feeding enhances expression IL-1β postprandial TNF-α genes cells.