A New Paradigm to Mitigate Osteosarcoma by Regulation of MicroRNAs and Suppression of the NF-κB Signaling Cascade

• DOI: 10.12717/dr.2014.18.4.197
• Publication Date: 2015-01-31T03:38:50Z
• Authors: Raj Kumar Mongre; Simrinder Singh S...; Mrinmoy Ghosh; Jeong Hyun Kim; Nameun Kim; Neelesh Sharma; Dong Kee Jeong
• Keywords: 0301 basic medicine; 03 medical and health sciences; Article; 3. Good health

Osteosarcoma (OS) is one of the most common malignant primary bone tumors and NF-κB appears to play a causative role, but mechanisms are poorly understood. OS pleomorphic, highly metastasized invasive neoplasm which capable generate osteoid, osteoclast osteoblast matrix. Its high incidence has been reported in adolescent children. Cell signal cascade pivotal functional mechanism acquired during differentiation, proliferation, growth survival cells including OS. The major limitation success chemotherapy development multidrug resistance (MDR). Answers all such queries might come from knock-in experiments combined approach miRNAs with pathway put into use. Abnormal can modulate several epigenetical switching as hallmark number diseases via different cell signaling. Studies on have opened up new avenues for both diagnosis treatment cancers Collectively, through present study an attempt made establish systematic investigation microRNAs, biophysiological factors their target pairs ameliorate oncogenesis "bridge between NF-κB". application inhibitors combination expected result more efficient killing cancer stem slower or less likely recurrence cancer.