Correlation between gut microbiota dysbiosis and colorectal cancer: review

• DOI: 10.12775/qs.2024.22.54326
• Publication Date: 2024-09-18T16:53:42Z
• Authors: Zuzanna Chilimoniuk; Dominik Dudziński; Aleksandra Borkowska; Aleksandra Chałupnik; Piotr Więsyk; Beata Chilimoniuk; Łukasz Gawłowicz; Filip Grzegorzak; Katarzyna Stasiak
• Keywords: Dysbiosis

Introduction and Purpose: The human gut microbiota, comprising a diverse consortium of approximately 100 trillion microorganisms, is integral to maintaining health modulating disease processes. Its development begins at birth, influenced by maternal microbiota environmental factors. Dysbiosis, defined as an imbalance in the microbial composition, has been implicated range gastrointestinal pathologies, including colorectal cancer (CRC). This review endeavors elucidate relationship between CRC, examining impact specific bacterial taxa on pathogenesis CRC. Description State Knowledge: Gut encompasses multitude species, with their composition differing along tract. Healthy perform essential functions such pathogen protection, metabolic processes, immune system modulation. Factors like diet genetics significantly influence composition. Dysbiosis contributes CRC through inflammation, genotoxin production, Specific bacteria, Fusobacterium nucleatum Bacteroides fragilis, are associated Mechanisms carcinogenesis include adherence, invasion epithelial cells, activation pro-inflammatory pathways. Summary:Understanding microbiota's role highlights importance balanced microbiome for prevention. Dietary interventions promoting beneficial bacteria reducing harmful species could mitigate risk. Further research should prioritize identification biomarkers early detection therapeutic strategies aimed microbiota. These efforts will enhance prevention treatment modalities.