Hepatoprotective and antidiabetic effects of apple cider vinegar (A Prophetic Medicine Remedy) on the liver of male rats

• DOI: 10.12816/0021418
• Publication Date: 2016-01-01
• Authors: Nassar Ayoub Abde...; Amal Nor Edeen Ah...; Salah Mohamed El ...
• Keywords: Lipid droplet; Histopathology; Infiltration (HVAC)

Background: Diabetes mellitus is associated with biochemical and pathological alterations in the liver. The aim of this study was to investigate effects apple cider vinegar (ACV) on serum markers histopathological changes liver diabetic rats for 30 days. Effects were evaluated using streptozotocin (STZ)-induced as an experimental model. Materials methods: induced by a single dose STZ (65 mg/kg) given intraperitoneally. Thirty wistar divided into three groups: control group, STZ-treated group plus ACV treated (2 ml/kg BW). Animals sacrificed days post treatment. Results: Biochemical results indicated that, caused significant decrease glucose, TC, LDL-c increase HDL-c. Histopathological examination sections showed fatty cytoplasm hepatocytes form accumulation lipid droplets, lymphocytic infiltration. Electron microscopic studies revealed aggregations polymorphic mitochondria apparent loss their cristae condensed matrices. Besides, rough endoplasmic reticulum proliferating fragmented smaller stacks. exhibited vacuolations displayed large number droplets different sizes. On other hand, minimal toxic due streptozotocin. These ultrastructural that treatment led recovery injured hepatocytes. In prophetic medicine, Prophet Muhammad peace upon him strongly recommended eating Prophetic Hadeeth: best edible. Conclusion: This ACV, early stages diabetes induction- can destructive progress cause hepatoprotection against metabolic damages resulting from streptozotocin- mellitus.