Relationship between Polycyclic Aromatic Hydrocarbon–DNA Adducts, Environmental Tobacco Smoke, and Child Development in the World Trade Center Cohort

• DOI: 10.1289/ehp.10144
• Publication Date: 2007-05-29T16:18:57Z
• Authors: Frederica P. Perera; Deliang Tang; Virginia Rauh; Yi Hsuan Tu; Wei Yann Tsai; Mark Becker; Janet L. Stein; Jeffrey King; Giuseppe Del Priore; Sally Ann Lederman
• Keywords: Cotinine; Cord blood; Tobacco smoke; Polycyclic aromatic hydrocarbon

Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are air pollutants released by the World Trade Center (WTC) fires and urban combustion sources. BaP-DNA adducts provide a measure of PAH-specific genetic damage, which has been associated with increased risk adverse birth outcomes cancer. We previously reported that levels in maternal umbilical cord blood obtained at delivery were elevated among subjects who had resided within 1 mile WTC site during month after 9/11; combination utero exposure to environmental tobacco smoke (ETS) significantly decreased fetal growth.Our aim was assess possible effects prenatal on child development.After 11 September 2001, we enrolled cohort nonsmoking pregnant women delivered three lower Manhattan hospitals. have followed subset children through their third birthdays measured cognitive motor development using Bayley-II Scales Child Development (BSID-II).In multivariate analyses, found significant interaction between ETS mental index score 3 years age (p = 0.02, n 98) whereas neither nor alone predictor (BSID-II) development.Although limited small numbers, these results suggest PAHs conjunction may contributed modest reduction children.