Personal PM2.5 Exposure and Markers of Oxidative Stress in Blood

• DOI: 10.1289/ehp.5646
• Publication Date: 2002-10-22T17:39:37Z
• Authors: Mette Sørensen; Bahram Daneshvar; Max Hansen; Lars O. Dragsted; Ole Hertel; Lisbeth Knudsen; Steffen Loft
• Keywords: Malondialdehyde

Ambient particulate air pollution assessed as outdoor concentrations of matter less than or equal to 2.5 micro m in diameter (PM(2.5)) urban background has been associated with cardiovascular diseases at the population level. However, significance individual exposure and involved mechanisms remain uncertain. We measured personal PM(2.5) carbon black 50 students four times 1 year analyzed blood samples for markers protein lipid oxidation, red cell (RBC) platelet counts, hemoglobin fibrinogen. oxidation terms gamma-glutamyl semialdehyde (HBGGS) 2-aminoadipic (HBAAS) plasma proteins (PLAAS), peroxidation was malondialdehyde (MDA) plasma. Median exposures were 16.1 g/m(3) exposure, 9.2 concentration, 8.1 X 10(-6)/m exposure. Personal PLAAS concentration positively (p < 0.01), whereas an association between only borderline = 0.061). A 3.7% increase MDA per 10 found women 0.05), there no significant relationship men. Similarly, positive associations PM(2.5)exposure both RBC 0.01). There relationships any biomarkers. This suggests that particles moderate can induce oxidative stress RBCs peripheral blood. appears more closely related these biomarkers potentially disease is ambient concentrations.