Effects of environmental oxidant stressors on individuals with a G-6-PD deficiency with particular reference to an animal model.

• DOI: 10.1289/ehp.792949
• Publication Date: 2011-05-04T17:01:43Z
• Authors: E J Calabrese; G Moore; R Brown
• Keywords: Stressor; Sodium chlorite

Individuals with a G-6-PD deficiency have long been known to be at increased risk experience acute hemolysis following exposure elevated levels of certain oxidant drugs and industrial chemicals. However, the recognition enhanced susceptibility environmental (or ambient) pollutants has generally not considered. Recent theoretical studies suggested that ambient ozone may an etiologic factor in onset deficient individual. Furthermore, proposed usage either chloramines or chlorine dioxide as replacements for disinfection drinking water should investigated respect their potential adverse effects individuals stressors. In order test these associations, two mouse strains, one low other high activity red blood cells are being determine if they simulate human normal individuals, respectively. Preliminary results indicate strain is markedly more susceptible sodium chlorite than mice strain. This differential toxicity between strains suggests further research designed validate efficacy this model predictor situation warranted.