Prioritizing Chemicals for Biomonitoring in ECHO to Maximize Public Health Impact

• DOI: 10.1289/isesisee.2018.s02.02.19
• Publication Date: 2019-11-25T19:56:41Z
• Authors: Tracey Woodruff; Jessie Buckley; David M Balshaw; Emily Barrett; Paloma Beamer; Michael S Bloom; Asa Bradman; Timothy Fennell; Rebecca Fry; William Funk; Kelsey Gleason; Ghassan Hamra; Christopher Heaney; Ramsunder Iyer; Margaret Rita Kar...; Kristen Lyall; Edo Pellizzari; Anne Starling; Aolin Wang; Deborah Watkins
• Keywords: Exposome; Environmental epidemiology; Exposure Assessment

Background: Environmental Influences on Child Health Outcomes (ECHO) is an NIH program linking 84 existing longitudinal cohorts of more than 50,000 children from across the US to understand effects environmental influences child health and development. ECHO represents unprecedented opportunity improve our understanding developmental chemical exposures during childhood their associations with a range adverse outcomes.Objective: We reviewed current exposure data available in provided framework for identifying informing future research activities. surveyed collect information cohort measurements through biomonitoring. developed prioritize research.Results Discussion: Out ECHO, about 60% have or planned biomonitoring data. More dozen classes chemicals are being measured. The most frequently measured biomarkers tobacco, phenols, phthalates. A smaller proportion measuring metals, PBDEs, PCBs, PAHs, organochlorine pesticides, organophosphate pesticides. Only handful perfluorinated compounds, pyrethroids, perchlorate, disinfection byproducts. Most prenatally at delivery, fewer childhood; few measure preconception paternal biomarkers. outcome focus areas include pregnancy outcomes, respiratory health, neurodevelopment, obesity. propose five categories priorities which consider degree scientific effects, opportunities new discovery, extent concern among public given historical bans/phase outs. will present analysis leverage this rich advance health.