Efficacy of leflunomide for treatment of refractory inflammatory colorectal polyps in 15 Miniature Dachshunds

• DOI: 10.1292/jvms.15-0129
• Publication Date: 2015-10-09T18:05:04Z
• Authors: Kenjiro FUKUSHIMA; Nozomi EGUCHI; Koichi OHNO; Hideyuki KANEMOTO; Masashi TAKAHASHI; Hirotaka IGARASHI; Aki OHMI; Ko NAKASHIMA; Hajime TSUJIMOTO
• Keywords: Leflunomide; Prednisolone; Refractory (planetary science); Leukocytopenia

Inflammatory colorectal polyp (ICRP), common in miniature dachshunds, presents with hematochezia, tenesmus and mucoid feces. Although an 80% response rate has been reported when treated prednisolone cyclosporine, effective treatment is needed for the remaining 20% of ICRP dogs. Leflunomide immunosuppressive drug as several immune-mediated diseases. In present study, we retrospectively evaluated efficacy adverse effects leflunomide 15 dogs that were refractory to cyclosporine. Treatment was assessed by endoscopy, clinical symptoms rectal palpation. Adverse determined blood testing during follow-up. The 93.3%. median dosage time 3 mg/kg (range: 1.7-4.0 mg/kg) 35 days 20-119 days), respectively. observed included lethargy (3 dogs), anorexia (1 dog), respiratory leukocytopenia (2 thrombocytopenia anemia dog) liver enzyme elevation (8 dogs). Most improved symptomatic discontinuation or reduction. conclusion, Because observed, close monitoring